Audio: Multinutrients for pregnancy & depression. 1st ever RCT NUTRIMUM trial. Benefits for mum & babies.

Science, stewardship & scalability.

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Audio: Multinutrients for pregnancy & depression. 1st ever RCT NUTRIMUM trial. Benefits for mum & babies.

No RCTs for antidepressants in pregnancy - but these studies demonstrate the benefits of nutrient mixtures, not only to treat depression symptoms, but for improved birth & infant outcomes.

Dec 13, 2024

Transcript

For a summary, links to University of Canterbury articles and links to the original YouTube clip (with screenshots of papers and graphs) please go to PSGR’s main Substack page on the NUTRIMUM studies.

REFERENCES:

Bradley HA, Campbell SA, Mulder RT, et al.(2020) Can broad-spectrum multinutrients treat symptoms of antenatal depression and anxiety and improve infant development? Study protocol of a double blind, randomized, controlled trial (the ‘NUTRIMUM’ trial). BMC Pregnancy Childbirth. 2020;20:488. doi: 10.1186/s12884-020-03143-z

Rucklidge JJ, Bradley HA, Campbell SA, Heaton JL, Mulder RT, Henderson J, et al. (2022) Vitamins and minerals treat antenatal depression and improve birth and infant development: results of the double-blind NutriMum RCT. AACAP/CACAP 2022 annual meeting. 2022;61:S283. doi: 10.1016/j.jaac.2022.07.579

Bradley HA, Moltchanova E, Mulder RT, Dixon L, Henderson J, Rucklidge JJ. Efficacy and safety of a mineral and vitamin treatment on symptoms of antenatal depression: 12-week fully blinded randomised placebo-controlled trial (NUTRIMUM). BJPsych Open. 2024 Jun 3;10(4):e119. doi: 10.1192/bjo.2024.706. PMID: 38828982; PMCID: PMC11363078.

Campbell SA, Bradley HA, Mulder RT, Henderson JMT, Dixon L, Haslett LC, Rucklidge JJ. (2024) Effect of antenatal micronutrient or antidepressant exposure on Brazelton neonatal behavioral assessment scale (NBAS) performance within one-month of birth. Early Hum Dev. 2024;190:105948. doi: 10.1016/j.earlhumdev.2024.105948

Campbell SA, Dys SP, Henderson JMT, Bradley HA and Rucklidge JJ (2024) Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life. Front. Nutr. 2024;11:1307701. doi: 10.3389/fnut.2024.1307701

Heaton, JL; Campbell, SA; Bradley, HA; Mulder, RT; Dixon, L; Henderson, J; Rucklidge, JJ. Broad-Spectrum Micronutrients or Antidepressants for Antenatal Depression: Effect on Maternal and Infant Birth Outcomes in an Observational Secondary Analysis of NUTRIMUM. Journal of Clinical Psychopharmacology ():10.1097/JCP.0000000000001934, December 2, 2024. | doi: 10.1097/JCP.0000000000001934

Carr, A.C.; Bradley, H.A.; Vlasiuk, E.; Pierard, H.; Beddow, J.; Rucklidge, J.J. Inflammation and Vitamin C in Women with Prenatal Depression and Anxiety: Effect of Multinutrient Supplementation. Antioxidants 2023, 12, 941. https://doi.org/10.3390/antiox12040941

Discussion about this episode

Science, stewardship & scalability.

Doctors & scientists talking about how policy-makers steward tech, pollution & open-ended systems to protect human & environmental health. Discussions traverse health, environment, agriculture, technology and governance. They shed light on why linear, technical approaches to risk assessment & regulation often create more problems in open-ended, biologically complex environments than they solve.

How can we identify & prevent tipping points to build resilience & protect health – from soil biology; to water systems; to our children and young people - who are being diagnosed with preventable conditions, at younger and younger ages?

Importantly: When policy and decisions around new laws rest upon science claims, how do 'we' create governance structures to prioritise the independent science & research that might inform policy & triangulate industry claims?

There's lots to talk about!

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